Ketamine activates the L-arginine/nitric oxide/cyclic guanosine monophosphate pathway to induce peripheral antinociception in rats

TRL Romero, GS Galdino, GC Silva… - Anesthesia & …, 2011 - journals.lww.com
… exhibits promise as a potential topical analgesic, the mechanistic basis of its peripheral
that ketamine can also elicit a peripheral antinociceptive effect in rat paw PGE 2 -induced

Involvement of the Larginine/nitric oxide/cyclic guanosine monophosphate pathway in peripheral antinociception induced by N‐palmitoyl‐ethanolamine in rats

TRL Romero, GS Galdino, GC Silva… - Journal of …, 2012 - Wiley Online Library
activates nNOS, thus initiating the NO/cGMP pathway and … Ketamine (80 μg/paw) was
administered 2 hr 55 min after local … , and the plantar surface of the rat paw was collected. This …

[HTML][HTML] Role of L-arginine/NO/cGMP/KATP channel signaling pathway in the central and peripheral antinociceptive effect of thymoquinone in rats

S Parvardeh, M Sabetkasaei, M Moghimi… - Iranian Journal of …, 2018 - ncbi.nlm.nih.gov
… Briefly, the rats were anesthetized with ketamine (60 mg/kg, IP) … of formalin in mice may locally
activate NOS and increase … in an increase in the cyclic guanosine monophosphate (cGMP) …

The involvement of nitric oxide in the analgesic effects of ketamine

F Bulutcu, A Dogrul, MO Güç - Life Sciences, 2002 - Elsevier
… , these data suggest that systemic ketamine activates the NO-cGMP pathway to produce …
ketamine produces antinociception in the acetic acid-induced writhing and formalin tests in mice

The N‐methyl‐D‐aspartate receptor antagonist ketamin exerts analgesic effects via modulation of the nitric oxide pathway

S Mahmoudzade, S Goudarzi… - Fundamental & …, 2022 - Wiley Online Library
… It is known that nitric oxide pathway is involved in antinociception … Methods: Ketamine
was administered to mice acute and … Ketamine activates the L-arginine/nitric oxide/cyclic

Inhibition of the l-argininenitric oxide pathway mediates the antidepressant effects of ketamine in rats in the forced swimming test

GF Zhang, N Wang, JY Shi, SX Xu, XM Li, MH Ji… - Pharmacology …, 2013 - Elsevier
… without inducing hyperactivity in the rats in the present study. … quickly reverses deficits in
spine density via activating the … of l-argininenitric oxide-cyclic guanosine monophosphate

Peripheral estradiol induces temporomandibular joint antinociception in rats by activating the nitric oxide/cyclic guanosine monophosphate signaling pathway

NC Favaro-Moreira, KE Torres-Chavez, L Fischer… - Neuroscience, 2009 - Elsevier
… The procedures were carried out under anesthesia induced by an im injection of a mixture
of ketamine (55 mg/kg) and xylazine (5.5 mg/kg). An sc injection of ketoprofen (5 mg/kg) was …

[HTML][HTML] The synthetic peptide PnPP-19 induces peripheral antinociception via activation of NO/cGMP/KATP pathway: Role of eNOS and nNOS

ACN Freitas, GC Silva, DF Pacheco, AMC Pimenta… - Nitric oxide, 2017 - Elsevier
… (SNP), induces antinociception in rat's paw made hyperalgesic with … of the L-arginine/nitric
oxide/cyclic guanosine monophosphateKetamine activates the L-arginine/Nitric oxide/cyclic

Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide–cGMP and PI3K/mTOR pathways

LEB Bettio, MP Cunha, J Budni, FL Pazini… - Behavioural brain …, 2012 - Elsevier
… of guanosine with ketamine in the TST was investigated. … similar biological effects (amnesic,
antinociceptive and … d-aspartate receptors and the l-arginine-nitric oxide pathway

The involvement of the endocannabinoid system in the peripheral antinociceptive action of ketamine

RCM Ferreira, MGM Castor, F Piscitelli, V Di Marzo… - The Journal of …, 2018 - Elsevier
… of the nitric oxide/cyclic guanosine monophosphate/adenosine … OEA, in rat paw tissues
after ketamine-induced counteraction of the … Ketamine activates the L-arginine/nitric oxide/cyclic